Nitrosamines are known to be carcinogenic and have the potential to be intermediates in organic synthesis. Due to their potent genotoxicity, nitrosamines have been a serious cause for concern. Accurate quantitate this group of compounds in pharmaceuticals during drug development and manufacturing has now become a requirement. Below, you will find the latest resources to help you improve your LC-MS quantitation of nitrosamines. If you looking to improve your nitrosamine analysis please do not hesitate to contact us.
Technique | Brand | Description | Recommended for: |
---|---|---|---|
HPLC | Gemini | 3 µm C18 150 x 4.6 mm | Ph. Eur. method for N-Nitrosamines in active substances |
HPLC | Kinetex | 2.6 µm Biphenyl 150 x 3 mm 2.6 µm Biphenyl 150 x 4.6 mm |
Sartan drugs, metformin and ranitidine |
HPLC | Kinetex | 2.6 µm F5 50 x 2.1 mm | Rapid analysis of genotoxic nitrosamines |
GC | Zebron | ZB-624plus 30 m x 0.25 mm x 1.40 µm | Analysis of NDMA and NDEA in sartan drugs |
HPLC | Luna Omega | 3 µm Polar C18 150 x 3 mm | Nitrosamine impurities in acyclovir |