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LC-MRM-MS Detection of Nitrosamines
Here, we present LC-MS methods capable of detecting highly polar nitrosamines at 0.007 ppm in the drug product, which is lower than the specification limit for NDMA. Three different stationary phases, a highly inert pentafluoro phenyl, an aqueous stable biphenyl, and a Polar C18 phase capable of providing excellent retention of polar nitrosamines with good peak shape were used for this purpose.
LC-MRM-MS Detection of Nitrosamines
Here, we present LC-MS methods capable of detecting highly polar nitrosamines at 0.007 ppm in the drug product, which is lower than the specification limit for NDMA. Three different stationary phases, a highly inert pentafluoro phenyl, an aqueous stable biphenyl, and a Polar C18 phase capable of providing excellent retention of polar nitrosamines with good peak shape were used for this purpose.
Document Type:
Poster
Target Industries:
Techniques:
Brands:
Separation Modes:
Reversed Phase
Phases:
LC-MRM-MS Detection of Nitrosamines
Here, we present LC-MS methods capable of detecting highly polar nitrosamines at 0.007 ppm in the drug product, which is lower than the specification limit for NDMA. Three different stationary phases, a highly inert pentafluoro phenyl, an aqueous stable biphenyl, and a Polar C18 phase capable of providing excellent retention of polar nitrosamines with good peak shape were used for this purpose.
| Target Industries: | Pharmaceutical |
| Techniques: | HPLC |
| Brands: | Kinetex, Luna HPLC Columns |
| Separation Modes: | Reversed Phase |
| Phases: | Kinetex Polar C18 |
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.