Clinical Research

From Clinical Sample Preparation to LC-MS Analysis, We Have You Covered

Our team of experts understands the challenges associated with Clinical Research; starting at the sample itself all the way through separation and analysis. Let us help you boost your throughput and improve your workflows with our portfolio of Sample Preparation and LC products that are sure to fit your needs.

Tackle challenging matrices with our portfolio of clinical sample preparation products
Achieve the sensitivity you need with our core-shell LC products
Reliably run your methods, day after day, with reproducible LC and Sample Preparation medias

Research Specialty Resources Hubs

Endocrine and Biomarker Analysis

Drug Analysis and Research

Industry Spotlight

Solid Phase Extraction

Testing Capabilities

Vitamin Testing

Trending Webinars

Simplifying Solid Phase Extraction for Faster and Cleaner Results

Method Development for SPE with Steroids

Sample Preparation Strategies for LC-MS/MS Analysis of Drugs in Difficult Matrices

Exploring LC Selectivity Using Steroids in a Clinical Setting

Trending Application Notes

Separation of Low Level Estrogen Analytes from Plasma by LC-MS/MS Analysis in Conjunction with Novum PRO Simplified Liquid Extraction (SLE)

Quantitation of Pain Panel Analytes from Oral Fluid Utilizing Microelution Solid Phase Extraction Coupled with LC-MS/MS

Steroid Panel Extraction from Plasma Using Novum PRO Simplified Liquid Extraction (SLE)

LC-MS/MS based Quantification of 47 Therapeutic Drug Monitoring Compounds in Serum: A Simple Sample Preparation Strategy for Efficient Analysis (TN-0159)

Quantitation of Clinical Research Steroid Analytes from Serum Utilizing Solid Phase Extraction with LC-MS/MS

Separation of Synthetic Benzodiazepines by SPE and LC-MS/MS

Feature Products

Kinetex Biphenyl

High-efficiency core-shell product (1.7, 2.6, or 5 µm) enhances separation of non-polar and polar compounds using hydrophobic, pi-pi, and dipole-dipole interactions.

Luna Omega C18

Advanced thermally modified (1.6, 3 or 5 µm) particle and bonding provides all purpose C18 selectivity, expanded retention and high batch-to-batch reproducibility.

Novum PRO

Faster, Easier, More Reliable: SLE Simplified. New Novum PRO SLE additionally gets down to low (LLOD) extraction levels from plasma with added clean manufacturing steps.

Strata-X PRO

New reversed phase polymer with matrix removal technology offers a faster, cleaner way to perform SPE. Learn how to reduce protocol time by at least 40%.

Top Tip

How do you pretreat a whole blood sample for SPE? A simple pretreatment is to add 10% TCA (trichloroacetic acid) aqueous solution in the ratio of 1:1. Centrifuge and collect the supernatant. Another simple way to pretreat whole blood is to perform protein precipitation with cold acetonitrile-methanol (85:15) in the ratio of 1:2. After centrifuging, the supernatant is diluted with solvent appropriate for extraction loading. A more thorough pretreatment is converting whole blood into blood plasma. Centrifuging anti-coagulated blood gives blood plasma as supernatant. Blood plasma preparation kits with prepackaged tubes containing an anticoagulant are commercially available. For more information on sample pretreatment for extraction using Strata and Strata-X, please contact us.
I have seen you have a number of different applications for Vitamin D, which ones should I consider? When attempting to analyze vitamin D, it is important to consider the source of the sample. That is, if samples are from a biological source the vitamin D is likely to be present as the 25-hydroxyvitamin D3 . The difficulty will be in separation of 25-hydroxy and 3-epi-25-hydroxy vitamin D3, and we have applications specific for this critical pair.If the separation is vitamin D from a food stuff or supplement, it will be present just as Vitamin D3 (cholecalciferol) and this is a much more straightforward separation. We have applications on this as well as other fat-soluble vitamins.

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