Frequently Asked Questions
Strata-Mag RP is a reversed-phase magnetic bead sample preparation technology designed for LC-MS workflows. It combines the selectivity of reversed-phase extraction with the simplicity of magnetic separation, enabling efficient sample cleanup and easy integration with automated laboratory workflows. It is particularly well suited for hydrophobic and weakly polar analytes commonly measured in clinical laboratories.
Strata-Mag RP is optimized for clinical LC-MS applications involving hydrophobic analytes, including reverse triiodothyronine (rT3), steroid hormones. These assays often demand effective matrix cleanup, high reproducibility, and scalable workflows to support growing testing volumes in clinical laboratories.
Unlike traditional SPE methods that rely on vacuum manifolds or positive-pressure systems, Strata-Mag RP uses magnetic separation to simplify extraction workflows. This can reduce hands-on time, minimize solvent consumption, eliminate flow-rate variability, and make automation easier while maintaining the sample cleanliness and performance expected from chromatography-based extraction methods.
Strata-Mag RP helps clinical laboratories simplify sample preparation while improving operational efficiency. Key benefits include: Reduced hands-on processing time Improved workflow reproducibility Lower dependence on highly skilled operators Easy implementation on automated platforms Lower solvent and consumable usage Scalable processing for high-throughput testing environments These advantages can help laboratories meet increasing sample volume demand for clinical assays while maintaining high data quality.
Yes. Strata-Mag RP was developed with automation compatibility in mind. The magnetic separation workflow can be incorporated into manual, semi-automated, or fully automated sample preparation platforms, helping laboratories increase throughput while reducing operator-to-operator variability.
Since you may not know beforehand which samples have high solvent levels, we recommend having a second GC instrument with an FID detector to screen incoming samples prior to GC-MS analysis to identify “hot” samples. This allows you to adjust the split ratio for the quantitative analysis and avoid detector saturation. This is particularly important when dealing with samples of unfamiliar origin.
Chromatography is the separation of components in a mixture based on their chemical nature. Chromatography can be performed in either liquid (HPLC) or gas (GC) forms. Liquid chromatography, specifically High Pressure Liquid Chromatography (HPLC), involves a stationary phase (sorbent), a mobile phase (liquid) and the analyte or compounds of interest. Analytes or compounds of interest are injected onto an HPLC column (packed with sorbent that contains a variety of chemistries) in mobile phase. As the mobile phase, which is carrying the analyte or compounds of interest, travels across the stationary phase, the analyte or compounds of interest separate from each other as they interact with the stationary phase, each eluting from the column at various times. Gas chromatography (GC) is similar to HPLC in that is utilized with working analytes or compounds of interest that can be vaporized without decomposing. In GC, gas is used instead of a liquid (like in HPLC). As analytes or compounds of interest travel in the gas mobile phase and interact with the stationary phase, eluting at various times.
Strata SE SLE utilizes a proprietary sorbent architecture that minimizes co-extracted matrix components, resulting in ultra-clean eluates. This reduces ion suppression/enhancement effects and improves signal-to-noise ratios in LC-MS/MS assays.
Strata SE SLE utilizes a proprietary sorbent architecture that minimizes co-extracted matrix components, resulting in ultra-clean eluates. This reduces ion suppression/enhancement effects and improves signal-to-noise ratios in LC-MS/MS assays.
Strata SE SLE utilizes a proprietary sorbent architecture that minimizes co-extracted matrix components, resulting in ultra-clean eluates. This reduces ion suppression/enhancement effects and improves signal-to-noise ratios in LC-MS/MS assays.
Strata SE SLE utilizes a proprietary sorbent architecture that minimizes co-extracted matrix components, resulting in ultra-clean eluates. This reduces ion suppression/enhancement effects and improves signal-to-noise ratios in LC-MS/MS assays.
Strata SE SLE utilizes a proprietary sorbent architecture that minimizes co-extracted matrix components, resulting in ultra-clean eluates. This reduces ion suppression/enhancement effects and improves signal-to-noise ratios in LC-MS/MS assays.