| 1Lovastatin |
|---|
| 2Simvastatin |
Compound Name Lovastatin |
CID 53232 |
Molecular Formula C24H36O5 |
Molecular Weight 404 |
No. Hydrogen Bond Acceptors 5 |
No. Hydrogen Bond Donors 1 |
Applications
Simvastatin by HPLC- Luna 5um C18(2) 250x4.6mm
19518
Separation Mode: Reversed Phase
Reversed Phase
C18(2)
HPLC
Antilipemic Agents
Analytes
Details
LC Conditions (App ID: 19518)
Column: | ||||||
Brand Name: | ||||||
Part No: | ||||||
Phase Name: C18(2) | ||||||
Elution Type: Isocratic | ||||||
Mobile Phase: A: 65:35 ACN:28mM sodium phosphate pH 4.5 | ||||||
Gradient Profile:
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Flow Rate: 1.5 mL/min | ||||||
Temperature: 45°C | ||||||
Detection: UV-Vis Abs.-Diode Array (PDA) @ 238 nm (22°C) | ||||||
Sample Note: For USP's system suitability requirements, the capacity factor for simvastatin must not be less than 3.0; column efficiency not less than 4500 theoretical plates; tailing factor not more than 2.0; resolution, while not specified according to USP standards, should be adequate at no less than 2.0. On the LUNA 5um C18(2) 250x4.6mm, the capacity factor for simvastatin is 4.6; column efficiency is 15,943; tailing factor is 0.985; and resolution between lovastatin and simvastatin is 9.54. |
Order Items Used in This Application
00G-4252-E0
Luna 5 µm C18(2) 100 Å, LC Column 250 x 4.6 mm, Ea
Qty:
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