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Claricep Flash Columns

Product Information
Brand
Seamlessly Upgrade to Claricep Flash Chromatography Columns
Claricep flash chromatography columns are packed with deactivated silica, resulting in column stability and better reproducible separations than traditional columns.

Seamlessly Upgrade to Claricep Flash Chromatography Columns

Available in two flash medias (Irregular and Spherical) with multiple chemistries optimized for resolution and high loading capacity.

Claricep Column

  • The deactivated silica surface promotes compound stability
  • Excellent peak shape and performance for both acidic and basic compounds
  • High quality and reproducibility
  • Wide range of selectivities
  • High pressure tolerance

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Flash Chemistries/Media

Claricep CM utilizes silica that is further purified with a proprietary acid washing process which results in even lower surface activity to result in an improved peak shape and resolution.

Consistent High Performance: High loading capacity (high surface area > 350m2/g) combined with good resolution for tight band definition (no tailing)
Wide Range of Selectivities: Variety of sorbents to meet any separation needs -(Silica (Si), C18, C8, AQ C18, Phenyl, Cyano (CN), Diol (OH), Amino (NH2) and HILIC (Urea) along with a large variety of cartridge sizes from 4 g to several kilograms allows for purification scale-up from milligrams to kilograms
High Pressure Tolerance: Exceptional durability to withstand high pressures due to closed-top spin-welded technology on standard hardware sizes that allows for pressure up to 12 bar (180 PSI)
Excellent Hardware: Universal luer fittings for compatibility with any flash system for great compound purity & recovery and 100% guaranteed leak-free.
High Quality: Consistent homogeneous packing allows for no channeling and creates reproducible high plate count (N).

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Claricep Deactivated Silica vs Traditional Unmodified Silica

claricep-graph-cm-comparison
Comparative separations may not be representative of all applications.
Flash Conditions:

Dimension
4.6 x 150 mm
Mobile Phase
Dichloromethane/Methanol (98:2)
Flow Rate
1.8 mL/min
Injection Volume
5 μL
Temperature
30 °C
Detector:
1.8 mL/min
UV @ 254 nm
1.8 mL/min
Sample
Catechol 100 μg/mL
HPLC TEST
Unmodified and Deactivated Silica were packed into individual stainless steel columns (4.6 x 150 mm) and then evaluated on a HPLC System

Irregular Silica Comparison

Ultra pure packing which results in much less abnormal surface activity. This produces chromatograms with much sharper peaks

Aniline Peak Symmetry and Retention Test

aniline-peak-symmetry-and-retention-test
Comparative separations may not be representative of all applications.
Flash Conditions:

Column
Claricep Irregular Silica CS (40-60 μm, 60 Å, 40 g)
Brand I
Flash Irregular Silica (40 g)
Mobile Phase
Dichloromethane/Methanol (99:1)
Flow Rate
20 mL/min
Detector
UV @ 254 nm
Temperature
Ambient
Retention Time
CLARICEP CS: 4.090 min
Brand I: 4.373 min
Sample
Aniline

Claricep CS vs. Popular Brand I

Flash Conditions:

Column
Claricep Irregular Silica CS
(40-60 μm, 60 Å, 40 g)
Brand I
Flash Irregular Silica Column (40 g)
Mobile Phase
Hexane/Ethylacetate (gradient)
Detector
UV @ 254 nm
Temperature
Ambient
Retention Time
CLARICEP CS: 4.090 min
Brand I: 4.373 min
Sample
Phenyl acetone,4-aminobenzoic acid

Claricep-cs-vs-popular-brand-I

Spherical Silica Comparison

Regular, similar-sized and high quality particles can be packed in a column much more uniformly which reduces eddy flow currents and lateral diffusion. The result is greater peak symmetry and baseline resolution than is possible with irregular silica particles.

Claricep Spherical Silica 20-30 µm vs. Claricep Spherical Silica 20 µm

claricep-spherical-comparison
Flash Conditions:

Column A
Claricep Spherical Silica (20-35 μm, 100 Å, 12 g, 2 columns in tandem)
Column B
Claricep Spherical Silica (20 μm, 100 Å, 12 g, 2 columns in tandem
Mobile Phase:
A: Hexane
B: Ethanol
Gradient:
Time (min)
0
20
 
% B
5
55
Flow Rate:
12 mL/min
Detector
UV @ 254/220 nm (ambient)
Samples:
0.2 mL

Chemistry Options

Irrregular
Spherical